Solid Phase Extraction
Short Description
CNW Solid Phase Extraction (SPE) products provide reliable sample cleanup, concentration, desalting, isolation, and purification before chromatography and other analytical workflows. The portfolio includes SPE sorbents, cartridges, disks, QuEChERS dispersive SPE products, vacuum manifolds, and supporting accessories for a broad range of sample matrices and analyte classes.
Category Description
Solid phase extraction is a sample-preparation technique in which liquid samples are processed through a selected solid sorbent to retain either the analyte of interest or interfering matrix components. By controlling the sorbent chemistry, sample solvent, wash conditions, and elution solvent, SPE helps simplify complex matrices and prepare samples for subsequent chromatographic or instrumental analysis.
CNW offers a comprehensive SPE portfolio covering adsorption, reversed-phase, normal-phase, ion-exchange, polymeric, and dual-layer sorbent chemistries. The CNWBOND range includes silica-based bonded phases and adsorption media, while the Poly-Sery range provides polymeric sorbent options. Complementary product formats include SPE tubes, SPE disks, dispersive SPE products for QuEChERS workflows, and vacuum manifold systems with accessories for parallel processing.
Explore SPE Solutions
SPE solution | Representative CNW chemistries or formats | Typical selection purpose |
|---|---|---|
Adsorption SPE | Si, Florisil, Alumina, Celite 545, Coconut Charcoal, Carbon-GCB | Cleanup of organic extracts and retention of polar matrix components |
Reversed-Phase SPE | C1, C2, C4, C8, C12, HC-C18, LC-C18, CYH, PHE | Extraction of mid- to nonpolar analytes from aqueous or moderately polar samples |
Normal-Phase SPE | CN, Diol | Separation of polar analytes from nonpolar matrices and selective cleanup of complex extracts |
Ion-Exchange SPE | NH2, PSA, WAX, SAX, WCX, SCX, PRS, C8/SAX, C8/SCX | Selective retention and recovery of ionic analytes through pH- and ionic-strength-controlled methods |
Polymeric SPE | PSD, XAD2, HLB, PWAX, MAX, MCX | Alternative selectivity for a broad range of sample-preparation workflows |
Dual-Layer SPE | GCB/PSA, GCB/SAX, SAX/PSA, Na₂SO₄/Florisil, GCB/NH₂/Si, GCB/SAX/PSA | Combined cleanup mechanisms for complex sample matrices |
QuEChERS dSPE | AOAC 2007 and EN 15662 method centrifuge tubes | Dispersive SPE cleanup for food, agricultural, and related sample workflows |
SPE Hardware & Accessories | Empty tubes, frits, adapters, vacuum manifolds, drying attachments, needles, disk manifolds | Efficient cartridge handling, parallel processing, collection, and workflow setup |
When to Select Solid Phase Extraction
Select SPE when direct analysis is affected by matrix interferences, insufficient analyte concentration, salts, pigments, lipids, proteins, or other unwanted components. Begin with the sample matrix and analyte properties, then choose a sorbent mechanism that provides the required retention and cleanup selectivity. Reversed-phase media are commonly selected for mid- to nonpolar analytes in aqueous matrices; normal-phase and adsorption media are suited to polar analytes or organic extracts; and ion-exchange media are selected when analyte charge can be controlled through sample pH.
For routine single-sample preparation, SPE tubes and appropriate adapters provide a practical format. For higher sample throughput, CNW SPE Vacuum Manifolds support continuous extraction and filtration across multiple samples. Select SPE disks or disk manifolds where the sample volume, throughput requirement, or extraction format calls for disk-based processing.
Key Advantages
CNW SPE solutions support simplified sample handling, reduced use of extraction solvent compared with conventional liquid-liquid extraction, and adaptable cleanup strategies across a wide variety of sorbent chemistries. The portfolio enables method development from basic sample cleanup through selective extraction, concentration, and matrix removal, with compatible hardware available to support manual and parallel SPE workflows.
Important Selection Note
SPE performance depends on the compatibility among the sample matrix, analyte chemistry, sorbent type, loading solvent, wash solvent, and elution conditions. Confirm retention and recovery using representative samples during method development. For ion-exchange SPE, carefully control sample pH and ionic strength; for silica-based phases, confirm solvent and pH suitability for the intended procedure.
